Anti-pcsk9 antibodies and use thereof

• Main Authors: Feldhaus, Andrew Lawrence, Ojala, Ethan, Dutzar, Benjamin H, Latham, John A, Fan, Pei, Akatsuka, Corinne C, Allison, Dan Scott, Mcneill, Patricia Dianne, Olson, Katie, Mitchell, Danielle, Stewart, Erica Ann, Kovacevich, Brian Robert, Garcia-Martinez, Leon F, Billgren, Jens
• Format: Patent
• Language: English
• Published: 26.10.2018
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.