Sheet molding and hemostatic material

• Main Authors: OONO AKITOSHI, KANEKO HIROAKI, KAGEYAMA YUKAKO, KAWAMURA RYOICHI, YAMAGUCHI AYUKO, SATAKE MAKOTO, IMAMURA TAKAYUKI, AKIYAMA YUSUKE, HONDA SUSUMU, FUJINAGA KENTARO, HIRASHIMA MASAKI
• Format: Patent
• Language: English
• Published: 24.06.2016
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed herein is a sheet product of a polymer composition that contains at least one type of protein substance selected from among the group consisting of fibrinogens and thrombins and at least one type of polymer selected from an aliphatic polyester and a water-soluble polymer, wherein the aliphatic polyester is selected from polylactic acid, polyglycolic acid, polycaprolactone, polyglycerol sebacate, polyhydroxyalkanoic acid, polybutylene succinate, a copolymer thereof, and a mixture thereof, the water-soluble polymer is selected from a polymer having an N-vinyl cyclic lactam unit, hydroxypropyl cellulose, methyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose, carboxymethyl cellulose sodium, a mixture thereof, polyethyleneoxide, polyvinylalcohol, hyaluronic acid, dextran, pullulan, starch, and a mixture thereof, and at least part of the protein is incorporated into the polymer composition as protein particles. Also disclosed is a laminated sheet molding containing a first polymer composition layer containing a fibrinogen and a water-soluble polymer and a second polymer composition layer containing a thrombin and an aliphatic polyester. These sheet moldings are applied to wound sites and function as hemostatic materials.