Antibodies that bind myostatin, compositions and methods

• Main Authors: HAN HQ, ZHOU XIAOLAN, LU HSIENG SEN, ARORA TARUNA, CHEN QING
• Format: Patent
• Language: English
• Published: 27.02.2015
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed is an isolated myostatin-specific antibody comprising at least one light chain and at least one heavy chain, wherein the light chain comprises a constant region and a variable region that comprises three complementarity determining regions (CDRs) and the heavy chain comprises a constant region and a variable region that comprises three CDRs, wherein the light chain CDR1, CDR2 and CDR3 are KASQDINKYVA, YTSWLQP and LQYDNLLYT, respectively, and the heavy chain CDR1, CDR2 and CDR3 are RYWMN, XIRLKSDNYATHYAESVKG and GLDY, respectively. Also disclosed is the use of the above-described myostatin-specific antibody in the preparation of a medicament for treatment or prevention of a disease or condition associated with activity of myostatin.