Pyrrolo-pyrazine derivatives useful as inhibitors of atr kinase

• Main Authors: CHARRIER JEAN-DAMIEN, VIRANI ANIZA NIZARALI, REAPER PHILIP MICHAEL, PINDER JOANNE, DURRANT STEVEN JOHN, KNEGTEL RONALD MARCELLUS ALPHONSUS, FRAYSSE DAMIEN, MACCORMICK SOMHAIRLE
• Format: Patent
• Language: English
• Published: 26.06.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are 2-(4-isopropylsulfonylphenyl)-pyrrolo[2,3-b]pyrazine derivatives and analogues as represented by the general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is phenyl substituted with one or two occurrences of J, where J is an aliphatic group which incorporates a...