Macrocycles as factor xia inhibitors

• Main Authors: PINTO DONALD J. P, FANG TIANAN, WANG YUFENG, SMALLHEER JOANNE M, JEON YOON, ROSSI KAREN A, CORTE JAMES R, HU ZILUN, QUAN MIMI L, YANG WU, DECICCO CARL P
• Format: Patent
• Language: English
• Published: 30.05.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

602266 Disclosed are compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. Also disclosed are pharm...