SUBSTITUTED HETEROARYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS

• Main Authors: TERINEK, MIROSLAV, DEPPE, HOLGER, HERZNER, HOLGER, RUMMEY, CHRISTIAN, FEURER, ACHIM, SIENDT, HERVE, HENNEBOHLE, MARCO, WEYERMANN, PHILIPP, SOEBERDT, MICHAEL, NORDHOFF, SONJA
• Format: Patent
• Language: English
• Published: 30.09.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The disclosure relates to substituted heteroarylpiperidine derivative (I) as melanocortin-4 receptor modulators. Depending on the structure and the stereochemistry these compounds of formula (I) are either selective agonists or selective antagonists of the human melanocortin-4 receptor (MC- 4R). The...