HUMAN ANTI-FOLATE RECEPTOR ALPHA ANTIBODIES AND ANTIBODY FRAGMENTS FOR THE RADIOIMMUNOTHERAPY OF OVARIAN CARCINOMA

Provided is an antibody or fragment thereof, which specifically binds to folate receptor-alpha (FRa), wherein said antibody or fragment thereof comprises a light chain, whose variable region comprises the complementarity-determining regions (CDRs) having the following amino acid sequences : - RASESV...

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Bibliographic Details
Main Authors CANEVARI, SILVANA, MAURIZI, GIOVANNI, FIGINI, MARIANGELA, CATTOZZO, MARGHERITA, MARTIN, FRANCK, DI CIOCCIO VITO
Format Patent
LanguageEnglish
Published 27.04.2012
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Provided is an antibody or fragment thereof, which specifically binds to folate receptor-alpha (FRa), wherein said antibody or fragment thereof comprises a light chain, whose variable region comprises the complementarity-determining regions (CDRs) having the following amino acid sequences : - RASESVSFLGINLIH, QASNKDT, LQSKNFPPYT, and wherein the constant region of said light chain is a kappa constant region and a heavy chain comprising the CDRs having the following amino acid sequences DYAMI , SISSSSSYIYYADSVKG , ERYDFWSGMDV. The medicament can be used to treat cancers.
Bibliography:Application Number: NZ20070575093