Process for the esterification of a carbothioic acid
Disclosed is a process for preparing compounds of formula: (II) by esterification of the C-17 hydroxyl group of 6alpha, 9alpha-difluoro-11beta, 17alpha-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carbothioic acid. The process comprises treating compound (I) with a slight excess of an acy...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English |
| Published |
31.03.2009
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| Edition | 7 |
| Online Access | Get full text |
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| Abstract | Disclosed is a process for preparing compounds of formula: (II) by esterification of the C-17 hydroxyl group of 6alpha, 9alpha-difluoro-11beta, 17alpha-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carbothioic acid. The process comprises treating compound (I) with a slight excess of an acyl chloride of general formula R-COCI, where R represents -CH2CH3, -CH2CH2CH3 or -CH(CH3)2, in an inert solvent, in the presence of a tertiary amine. Preferably the process is carried out using pyridine in the presence of acetone at a temperature of from 5°C to -20 °C. |
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| AbstractList | Disclosed is a process for preparing compounds of formula: (II) by esterification of the C-17 hydroxyl group of 6alpha, 9alpha-difluoro-11beta, 17alpha-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carbothioic acid. The process comprises treating compound (I) with a slight excess of an acyl chloride of general formula R-COCI, where R represents -CH2CH3, -CH2CH2CH3 or -CH(CH3)2, in an inert solvent, in the presence of a tertiary amine. Preferably the process is carried out using pyridine in the presence of acetone at a temperature of from 5°C to -20 °C. |
| Author | HEGGIE, WILLIAM LEITAO, EMILLIA SOBRAL, LUIS MARTIN, DIONISIO |
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| Title | Process for the esterification of a carbothioic acid |
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