Formulations of suberoylanilide hydroxamic acid and methods for producing same

• Main Authors: MOSER, JUSTIN, GALLAGHER, KIMBERLY, TUNG, HSIEN-HSIN, STARBUCK, CINDY, COTE, AARON S, COHEN, BENJAMIN MAX, REED, ROBERT A, WONG, JEANNIE CHOW, IKEDA, CRAIG, DIENEMANN, ERIK A, CAPODANNO, VINCENT R, MILLER, THOMAS A, RAJNIAK, PAVOL, WANG, QINGXI, SELL, BRIAN
• Format: Patent
• Language: English
• Published: 30.09.2011
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided is a process of producing a pharmaceutical composition comprising crystalline suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof, comprising the steps of: (a) blending 60-5% of a first batch of crystalline suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof having a mean particle size of less than 60 micrometers and 40-95% of a second batch of crystalline suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof having a mean particle size of 100-250 micrometers; and (b) encapsulating a portion of the blended crystalline suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof to produce the pharmaceutical composition.