2-pyrazolin-5-ones

A 2-pyrazolin-5-one or physiologically acceptable salts thereof useful as a protein kinase inhibitor has the formula (I) wherein R is optionally substituted indole, imidazole, 1,2,3-triazole, 1,2,4-triazole, benzimidazole, 4,5,6,7-tetrahydroindole, benzoindole, azaindole, indazole, pyridine, quinoli...

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Main Authors FERNANDEZ, ISABEL F, CALDERWOOD, DAVID J, RAFFERTY, PAUL, MOSET, MARINA M, BERLANGA, JOSE MARIA CASTELLANO, ARNOLD, LEE
Format Patent
LanguageEnglish
Published 24.09.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A 2-pyrazolin-5-one or physiologically acceptable salts thereof useful as a protein kinase inhibitor has the formula (I) wherein R is optionally substituted indole, imidazole, 1,2,3-triazole, 1,2,4-triazole, benzimidazole, 4,5,6,7-tetrahydroindole, benzoindole, azaindole, indazole, pyridine, quinoline, pyrimidine, benzene, pyrazine, pyrrole, pyrazole, oxazole or thiazole; R1 is hydrogen or -A-Z; A is -(CH2)n-, -(CH2)n-NH-, -(CH2)n-O-, -(CH2)n-S-, -(CH2)n-S(O)- or -(CH2)n-S(O)2-; Z is -H, alkyl, aralkyl, trihalomethyl, trihalomethylcarbonyl, R3OC(O)-, -NR4R5, -C(O)NR4R5, R3CO-, R3O-, or an optionally substituted cycloalkane, isoxazole, isothiazole, imidazole, benzene, pyrrole, indole, pyridine, pyrazine, pyrimidine, benzothiazole, tetrahydrofuran, thiophene, imidazole, furan, triazine, benzimidazole, pyridazine, quinoxaline, pyrazole, oxazole, thiazole or N-oxides thereof; n is 0 to 3 and R3 to R5 are as defined in the specification limited by the provisos listed in the specification.
Bibliography:Application Number: NZ20000516850