Triptolide derivatives substituted with amino acids, useful in the treatment of autoimmune diseases

Compounds of formula (I), (II) and (III) may be used in medicaments for the treatment of an autoimmune disease, particularly rheumatoid arthritis. In formula (I), (II) and (III); X is I, Br, Cl, F or -CN; R1 and R2 are each independently is H or -OR5; R3 is H, -C(=O)(CH2)nCO2H or an amino acid; R4 i...

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Bibliographic Details
Main Authors WICKRAMARATNE, MAHINDA, HEPPERLE, MICHAEL, JUNG, MICHEL J
Format Patent
LanguageEnglish
Published 31.08.2001
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of formula (I), (II) and (III) may be used in medicaments for the treatment of an autoimmune disease, particularly rheumatoid arthritis. In formula (I), (II) and (III); X is I, Br, Cl, F or -CN; R1 and R2 are each independently is H or -OR5; R3 is H, -C(=O)(CH2)nCO2H or an amino acid; R4 is H or -OH; R5 is H, -C(=O)(CH2)nCO2H or an amino acid; n is the integer 2, 3, 4, 5 or 6; provided that R1 and R2 are H when R3 is other than H.
Bibliography:Application Number: NZ19980500762