Tricykliske triazolbenzazepinderivater, fremgangsmate til fremstilling derav, samt antiallergiske midler

• Main Authors: SHIOKAWA SOHJIRO, TAKATA HIROMI, SHIOBARA MAKI, FUSHIHARA KENICHI, MIYAMOTO SACHIKO, NISHIZUKA TOSHIO, OKADA YUMIKO, KAWAGUCHI MAMI, TSUTSUMI SEIJI, ISHIKURA TOYOAKI, KITAGAWA HIDEO, OHTSUKA YASUO, SHISHIKURA TAKASHI
• Format: Patent
• Language: Norwegian
• Published: 29.08.2005
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Tricyclic triazolobenzazepine derivatives in the form of a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. wherein R represents hydrogen, OH, alkyl or phenyl alkyl, R , R , R , and R represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, and Q represents a group selected from the following groups (i) to (iv), halogen, or alkoxy: