Setedirigert modifikasjon av FVIII

• Main Authors: Pan, Clark Q, Murphy, John E, Wang, Deqian, Mei, Baisong, Chen, Jianmin, Barnett, Thomas, Tang, Liang, Strauss, Jonathan S, Tjandra, Hendri
• Format: Patent
• Language: Norwegian
• Published: 27.06.2007
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.