Setedirigert modifikasjon av FVIII

This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.

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Bibliographic Details
Main Authors Pan, Clark Q, Murphy, John E, Wang, Deqian, Mei, Baisong, Chen, Jianmin, Barnett, Thomas, Tang, Liang, Strauss, Jonathan S, Tjandra, Hendri
Format Patent
LanguageNorwegian
Published 27.06.2007
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
AbstractList This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
Author Murphy, John E
Strauss, Jonathan S
Chen, Jianmin
Pan, Clark Q
Mei, Baisong
Wang, Deqian
Barnett, Thomas
Tjandra, Hendri
Tang, Liang
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– fullname: Chen, Jianmin
– fullname: Barnett, Thomas
– fullname: Tang, Liang
– fullname: Strauss, Jonathan S
– fullname: Tjandra, Hendri
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Snippet This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible...
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SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Setedirigert modifikasjon av FVIII
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