PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the formula: [Formula] where A, U, w1, w2, w3, R1-R6, And R9 are described herein.

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Bibliographic Details
Main Authors LU, WEI, CARAVELLA, JUSTIN ANDREW, ERICSSON, ANNA, CAMPBELL, ANN-MARIE, LIN, JIAN, GUSTAFSON, GARY, WANG, ZHONGGUO, ASHWELL, SUSAN, LANCIA, DAVID R, DIEBOLD, R. BRUCE
Format Patent
LanguageEnglish
Published 21.06.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the formula: [Formula] where A, U, w1, w2, w3, R1-R6, And R9 are described herein.
Bibliography:Application Number: MY2020PI01463