BISPECIFIC MOLECULES HAVING IMMUNOREACTIVITY WITH PD-1 AND CTLA-4, AND METHODS OF USE THEREOF

• Main Authors: SCOTT KOENIG, SHAH, KALPANA, A. MOORE, PAUL, CHICHILI, GURUNADH REDDY, S. JOHNSON, LESLIE, BONVINI, EZIO, LA MOTTE-MOHS, ROSS
• Format: Patent
• Language: English
• Published: 03.05.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention is directed to bispecific molecules (e.g., diabodies, bispecific antibodies, trivalent binding molecules, etc.) that possess at least one epitope-binding site that is immunospecific for an epitope of PD-1 and at least one epitope-binding site that is immunospecific for an epito...