CRYSTAL OF 3,5-DISUBSTITUTED BENZENE ALKYNYL COMPOUND
An object of the present invention is to provide a crystal of (S)-1-(3-(4-amino-3-((3,5-dimethoxyphenyl)ethynyl)-1H- pyrazolo[3,4-d]pyrimidin-1-yl)-1-pyrrolidinyl)-2-propen-1-one, which is useful as an antitumor agent, the crystal being stable, excellent in oral absorbability, highly chemically pure...
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Main Author | |
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Format | Patent |
Language | English |
Published |
13.03.2023
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Subjects | |
Online Access | Get full text |
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Summary: | An object of the present invention is to provide a crystal of (S)-1-(3-(4-amino-3-((3,5-dimethoxyphenyl)ethynyl)-1H- pyrazolo[3,4-d]pyrimidin-1-yl)-1-pyrrolidinyl)-2-propen-1-one, which is useful as an antitumor agent, the crystal being stable, excellent in oral absorbability, highly chemically pure, and suitable for mass production. The present invention provides a crystal of (S)-1-(3-(4-amino-3-((3,5-dimethoxyphenyl)ethynyl)-1H- pyrazolo[3,4-d]pyrimidin-1-yl)-1-pyrrolidinyl)-2-propen-1-one that exhibits an X-ray powder diffraction spectrum containing at least three characteristic peaks at diffraction angles selected from 9.5?, 14.3?, 16.7?, 19.1?, 20.8?, 21.9?, and 25.2?. The present invention also provides a crystal of (S)-1-(3-(4- amino-3-((3,5-dimethoxyphenyl)ethynyl)-1H-pyrazolo[3,4- d]pyrimidin-1-yl)-1-pyrrolidinyl)-2-propen-1-one that exhibits an X-ray powder diffraction spectrum containing at least seven characteristic peaks at diffraction angles (2?? 0.2? ) selected from 13.5?, 17.9?, 19.5?, 20.6?, 22.0?, 22.6?, 23.3?, 23.7?, and 24.2?. |
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Bibliography: | Application Number: MY2017PI703525 |