ANTIBODIES AGAINST CD73 AND USES THEREOF

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding...

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Main Authors SCHWEIZER, Liang, HATCHER, Sandra, V, MYERS, Joseph, E, SEGA, Emanuela, HUANG, Richard, LEI, Ming, LONBERG, Nils, SRINIVASAN, Mohan, CORBETT, Martin, J, KORMAN, Alan, J, BARNHART, Bryan C, HUANG, Haichun, CHEN, Guodong, YAMNIUK, Aaron, P, JURE-KUNKEL, Maria, N, SACK, John, HENNING, Karla A, ZHANG, Pingping, GOODENOUGH, Angela
Format Patent
LanguageEnglish
Published 11.03.2022
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Abstract The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.
AbstractList The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.
Author HENNING, Karla A
HATCHER, Sandra, V
ZHANG, Pingping
GOODENOUGH, Angela
HUANG, Haichun
YAMNIUK, Aaron, P
SEGA, Emanuela
LONBERG, Nils
SCHWEIZER, Liang
BARNHART, Bryan C
MYERS, Joseph, E
HUANG, Richard
CORBETT, Martin, J
CHEN, Guodong
SACK, John
SRINIVASAN, Mohan
KORMAN, Alan, J
LEI, Ming
JURE-KUNKEL, Maria, N
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– fullname: SEGA, Emanuela
– fullname: HUANG, Richard
– fullname: LEI, Ming
– fullname: LONBERG, Nils
– fullname: SRINIVASAN, Mohan
– fullname: CORBETT, Martin, J
– fullname: KORMAN, Alan, J
– fullname: BARNHART, Bryan C
– fullname: HUANG, Haichun
– fullname: CHEN, Guodong
– fullname: YAMNIUK, Aaron, P
– fullname: JURE-KUNKEL, Maria, N
– fullname: SACK, John
– fullname: HENNING, Karla A
– fullname: ZHANG, Pingping
– fullname: GOODENOUGH, Angela
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Snippet The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high...
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METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Title ANTIBODIES AGAINST CD73 AND USES THEREOF
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