FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND TO MYOSTATIN

• Main Authors: ZHAO, Wenjun, LIPOVSEK, Dasa, KRYSTEK, Stanley, Richard, Jr, MADIREDDI, Malavi, WEI, Hui, KOZHICH, Alexander, T, ENGLE, Linda, RAKESTRAW, Ginger, Chao, CORBETT, Martin, J, SWAIN, Joanna, RAMAMURTHY, Vidhyashankar, CLOAD, Sharon, YAMNIUK, Aaron, P
• Format: Patent
• Language: English
• Published: 25.02.2022
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES

The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic ki...