5-SUBSTITUTED-2-PHENYLAMINO BENZAMIDES AS MEK INHIBITORS

• Main Authors: TAKESHI MURATA, SHINJI TSUJII, MASANORI MIWA, YASUAKI MATSUBARA, NOBUO SHIMMA, YOSHIAKI ISSHIKI, YASUNORI KOHCHI, EISAKU MIZUGUCHI, MASAMI KOHCHI, HITOSHI IIKURA, SATOSHI AIDA, KOSUKE ASO
• Format: Patent
• Language: English
• Published: 15.08.2011
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

AN OBJECTIVE OF THE PRESENT INVENTION IS TO PROVIDE COMPOUNDS THAT EXHIBIT STRONG MEK-INHIBITING ACTIVITY AND ARE STABLE IN VIVO AND SOLUBLE IN WATER, WHICH CAN BE USED AS PREVENTIVE OR THERAPEUTIC AGENTS FOR PROLIFERATIVE DISEASES. THE COMPOUNDS OF THE PRESENT INVENTION AND PHARMACEUTICALLY ACCEPTA...