CHIMERIC CHAINS CODING FOR PROTEINS INDUCING EFFECTS AGAINST VIRUS

• Main Authors: CHINEA SANTIAGO, GLAY, GUILLEN NIETO, GERARDO ENRIQUE, GUZMAN TIRADO, MARIA GUADALUPE, VALDES PRADO, IRIS, LAZO VAZQUEZ, LAURA, HERMIDA CRUZ, LISSET, ESPINOSA PEREZ, RAUL RAFAEL, SIERRA VAZQUEZ, BEATRIZ DE LA CARIDAD, RODRIGUEZ DIAZ, RAYNER, SILVA RODRIGUEZ, RICARDO DE LA C, ZULUETA MORALES, AIDA, LOPEZ ABARRA TEGUI, CARLOS
• Format: Patent
• Language: English
• Published: 30.06.2009
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

THE PRESENT INVENTION IS RELATED TO THE OBTAINING OF CHIMERIC CHAINS CODING FOR PROTEINS CAPABLE OF INDUCING, IN THE RECIPIENT, A SEROTYPE-SPECIFIC AND PROTECTIVE HUMORAL IMMUNE RESPONSE AGAINST THE INFECTION BY THE DENGUE VIRUS THUS ELIMINATING THE EFFECTS OF THE SEROTYPE-NONESPECIFIC VIRAL IMMUNOENHANCEMENT THAT CAUSES HERMORRHAGIES AND CLINICAL COMPLICATIONS DESCRIBED FOR THIS KIND OF PATHOLOGY. THESE CHIMERIC CHAINS OF NUCLEIC ACIDS ARE COMPOSED BY THE SPECIFIC COMBINATION OF FRAGMENTS BELONGING TO THE GENE OF A MUTATED PROTEIN FROM NEISSERIA MENINGITIDIS WITH DEHYDROGENASE ACTIVITY AND FRAGMENTS THAT CODIFY FO A REGION OF THE ENVOLOPE (E) PROTEIN FROM THE DENGUE VIRUS WHICH, WHEN INSERTED TO AN EXPRESSION VECTOR, GIVE RISE TO CHIMERIC PROTEINS WITH PARTICULAR PROPERTIES. THE RESULTANT CHIMERIC MOLECULES FROM THIS INVENTION ARE APPLICABLE TO THE PHARMACEUTICAL INDUSTRY FOR THE OBTAINING OF VACCINE PREPARATIONS AND DIAGNOSTIC MEANS OF HIGH SEROTYPE-SPECIFICITY TO BE USED IN HUMANS.