CATALYTIC PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES

A process for the preparation of a compound of formula (I) wherein Q is CH or N; Y is NO2 or CN; Z is CHR3, O, NR3 or S; R1 and R2 are C1-C8 alkyl or together form an alkylene bridge having two or three carbon atoms; by reacting a compound of formula H2C=C(X)CH2NCS wherein X is a leaving group, with...

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Bibliographic Details
Main Author RAPOLD, THOMAS
Format Patent
LanguageEnglish
Spanish
Published 06.06.2003
Edition7
Subjects
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for the preparation of a compound of formula (I) wherein Q is CH or N; Y is NO2 or CN; Z is CHR3, O, NR3 or S; R1 and R2 are C1-C8 alkyl or together form an alkylene bridge having two or three carbon atoms; by reacting a compound of formula H2C=C(X)CH2NCS wherein X is a leaving group, with a chlorinating agent in the presence of a catalytic amount of SO2. to form a compound of formula (III) and the compound of formula (III) is reacted with a compound of formula R1NHC(=QY)ZR2 wherein R1, R2, Y, Z and Q are as defined for compound (I).
Bibliography:Application Number: MX2003PA01550