2-AMINO-4H-3,1-BENZOXAZIN-4-ONE DERIVATIVES FOR THE TREATMENT OF OBESITY

• Main Author: HODSON, HAROLD, FRANCIS
• Format: Patent
• Language: English; Spanish
• Published: 04.06.2003
• Edition: A
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

The use of a compound comprising formula (I) or a salt, ester, amide or prodrug therof in the inhibition of an enzyme whose preferred mode of action is to catalyse the hydrolysis of an ester functionality, e.g. in the control and inhibition of unwanted enzymes in products and processes. The compounds are also useful in medicine e.g. in the treatment of obesity and related conditions. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I) A is a 6-membered aromatic or heteroaromatic ring; and R1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups. El uso de un compuesto que comprende la formula (I) o una sal, ester, amida o profarmaco del mismo en la inhibicion de una enzima cuyo modo preferido de accion es catalizar la hidrolisis de una funcionalidad de ester, por ejemplo, en el control y la inhibicion de enzimas no deseadas en los productos y procesos. Los compuestos tambien son utiles en la medicina, por ejemplo, en el tratamiento de la obesidad y condiciones relacionadas. La invencion tambien se refiere a compuestos nuevos dentro de la formula (l), a procesos para prepararlos y composiciones farmaceuticas que los contienen. En la formula (I) A es un anillo aromatico o heteroaromatico de 6 miembros; R1 es un alquilo ramificado o no ramificado (opcionalmente interrumpido por uno o mas atomos de oxigeno), alquenilo, alquinilo, cicloalquilo, cicloalquenilo, arilo, arilalquilo, arilalquilo reducido, arilalquenilo, heteroarilo, heteroarilalquilo, heteroarilaquenilo, arilo reducido, heteroarilo reducido, heteroarilalquilo reducido o un derivado sustituido de cualquiera de los grupos precedentes.