METHOD FOR PREPARING STREPTOGRAMINES

• Main Authors: LUC GRONDARD, JEAN-CLAUDE BARRIERE, STEPHANE MUTTI, PATRICK LEFEVRE
• Format: Patent
• Language: English; Spanish
• Published: 29.11.1997
• Edition: 6
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

A method for preparing streptogramines of general formula (I), wherein R1 is methyl or ethyl, R2 is H and X and Y together form an oxo radical, or R1 is ethyl, R2 and X are H and Y is H or OH, or else R1 is ethyl, R2 is OH and X and Y together form an oxo radical, by demethylating a synergistin derivative of general formula (II), wherein R1, R2, X and Y are as defined above, by means of a treatment with a periodate in an acetic medium, followed by a treatment in an aqueous medium. Procedimiento de preparacion de estreptograminas de formula general (I): en la cual ya sea R1 es metilo o etilo, R2 es H y X y Y forman juntos un radical oxo, ya sea R1 es etilo, R2 y X representan H y Y es H o OH, ya sea R1 es etilo R2 es OH, y X y Y forman juntos un radical oxo, por desmetilacion de un derivado de sinergistina de formula general.