1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS

• Main Authors: Linghong XIE, Noel Aaron POWELL, Vadim ALEXANDROV, Philip Glyn JONES, Kerry L. SPEAR, Taleen G. HANANIA
• Format: Patent
• Language: English; Spanish
• Published: 29.01.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are compounds of Formula (I): (Formula (I)) and pharmaceutically acceptable salts thereof, wherein A, Ra, R1, R2, R3, R4, R6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein. Se describen compuestos de la Fórmula (I): (ver Fórmula) y sales farmacéuticamente aceptables de los mismos, en donde A, Ra R1, R2, R3, R4, R6, w y n1 se definen y describen en la presente; composiciones de los mismos; y métodos de uso de los mismos. Estos compuestos son útiles para tratar una variedad de trastornos neurológicos y psiquiátricos, tales como los descritos aquí.