SOLID FORMS OF 4-(5-(4-FLUOROPHENYL)-6-TETRAHYDRO-2H-PYRAN-4-YL)- 1,5-DIHYDROPYRROLO[2,3-F]INDAZOL-7-YL)BENZOIC ACID

Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydrop yrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and metho...

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Main Authors RODAY Setu, GIROUX Simon, SAWANT Rupa, SONG Zhengtian, SOKOLOWSKY Kathleen Paige, LIU Siying, SPOSATO Marisa, HU Kan-nian, OVERHOFF Kirk Alan, TORRICO GUZMAN Elisa A, MEDEK Ales, SHI Yi, LAI Mei-hsiu
Format Patent
LanguageEnglish
Spanish
Published 31.07.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydrop yrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1) capable of modulating alpha-1 antitrypsin (AAT) activity and methods of treating alpha-1 antitrypsin deficiency (AATD) by administering one or more such forms, and methods of using and preparing the same for treatment of alpha-1 antitrypsin deficiency (AATD). Formas sólidas del ácido 4-(5-(4-fluorofenil)-6- (tetrahidro-2H-piran-4-il)-1,5-dihidropirrolo[2,3-f]indazol-7-il) benzoico (Compuesto 1) capaces de modular la actividad de la alfa-1 antitripsina (AAT) y métodos para tratar la deficiencia de alfa-1 antitripsina (AATD) al administrar una o más de estas formas, y métodos de uso y preparación de las mismas para el tratamiento de la deficiencia de la alfa-1 antitripsina (AATD).
Bibliography:Application Number: MX20230005589