PRMT5 INHIBITORS

The present invention provides a compound selected from: and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds disclosed herein, pharmaceutical compositions comprising compounds disclosed herein, and methods...

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Bibliographic Details
Main Authors MACHACEK Michelle, WITTER David J, SLOMAN David L, GIBEAU Craig R, KAWAMURA Shuhei, ALTMAN Michael D
Format Patent
LanguageEnglish
Spanish
Published 23.09.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides a compound selected from: and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds disclosed herein, pharmaceutical compositions comprising compounds disclosed herein, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations. La presente invención proporciona un compuesto seleccionado de: (ver Fórmulas) y las sales, ésteres y profármacos farmacéuticamente aceptables de los mismos, que son inhibidores de PRMT5. También se proporcionan métodos para hacer compuestos descritos en la presente, composiciones farmacéuticas que comprenden los compuestos descritos en la presente y métodos para usar estos compuestos para tratar el cáncer, células falciformes y persistencia hereditaria de mutaciones de la hemoglobina fetal (HPFH).
Bibliography:Application Number: MX2022007534