DIRECTED CONJUGATION TECHNOLOGIES

Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, p...

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Bibliographic Details
Main Authors BERBASOVA Tetyana, IBEN Lawrence Gerald, VIDAL Christian Marcel, RASTELLI Luca, SPIEGEL David Adam, CUKAN Michael C, ALVAREZ Enrique, VAILL Ada Margaret, WELSCH Matthew Ernest, BUNIN Anna
Format Patent
LanguageEnglish
Spanish
Published 15.08.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates. Entre otras cosas, la presente divulgación proporciona tecnologías para conjugación dirigida al sitio de diversas porciones de interés hacia agentes diana. En algunas formas de realización, la presente divulgación utiliza porciones de unión a la diana para proporcionar una alta eficiencia de conjugación y selectividad. En algunas formas de realización, las tecnologías proporcionadas son útiles para preparar conjugados de anticuerpo.
Bibliography:Application Number: MX2022005884