BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS

• Main Authors: Christoph Wolfgang ZAPF, David Randolph ANDERSON, Kevin Joseph CURRAN, Joseph Walter STROHBACH, Eddine SAIAH, Christoph Martin DEHNHARDT, Stephen Wayne WRIGHT, Michael Dennis LOWE, John David TRZUPEK, Horng- Chih HUANG, Lori Krim GAVRIN, Arthur LEE, Betsy Susan PIERCE, Xiaolun WANG, Seungil HAN, Katherine Lin LEE, Mark Edward BUNNAGE, Joel Adam GOLDBERG, Richard VARGAS, Nikolaos PAPAIOANNOU, David HEPWORTH, Frank Eldridge LOVERING, Akshay PATNY, John Paul MATHIAS
• Format: Patent
• Language: English; Spanish
• Published: 09.01.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. Se describen compuestos, tautómeros y sales de estos aceptables desde el punto de vista farmacéutico, en donde los compuestos tienen la estructura de la Fórmula la: (ver Fórmula) como se definieron en la memoria descriptiva. También se describen composiciones farmacéuticas, métodos de tratamiento, métodos de síntesis e intermediarios correspondientes.