Pharmaceutical formulations of Bruton's tyrosine kinase inhibtor

• Main Authors: TAN Heow, ATLURI Harisha, KUEHL Robert, CHONG Ching Wah
• Format: Patent
• Language: English; Romanian
• Published: 31.05.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Prezenta invenţie descrie formulări farmaceutice ale inhibitorului tirozin kinazei Bruton (Btk) 1-((R)-3-(4-amino-3-(4-fenoxifenil)-1H-pirazolo[3,4-d]pirimidin-1-il)piperidin-1-il)prop-2-en-1-onă. Sunt dezvăluite şi metode folosind inhibitorul Btk, singur sau în combinaţie cu alţi agenţi terapeutici, pentru tratamentul bolilor sau tulburărilor autoimune, bolilor sau tulburărilor heteroimune, cancerului, inclusiv limfomului şi bolilor sau tulburărilor inflamatorii. Described herein are pharmaceutical formulations of Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Also disclosed are methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.