PYRROLES TRICYCLIQUES CONDENSÉS UTILISÉS COMME MODULATEURS DE L'ALPHA-1 ANTITRYPSINE

• Main Authors: COTTRELL, Kevin Michael, GAGNON, Kevin James, LOOKER, Adam, BOYD, Michael John, ZAKY, Mariam, GARCIA BARRANTES, Pedro Manuel, FLEMING, Gabrielle Simone, RODAY, Setu, GIACOMETTI, Robert Daniel, FANNING, Lev Tyler Dewey, JOHNSON, JR., Mac Arthur, RONKIN, Steven M, STAVROPOULOS, Kathy, KESAVAN, Sarathy, THOMSON, Stephen, JONES, Peter, SAWANT, Rupa, GUIDO, Samantha, HOOD, Sarah Carol, SWETT, Rebecca Jane, NUHANT, Philippe Marcel, SHI, Yi, SHRESTHA, Muna, MAXWELL, Brad, BOUCHER, Diane, SPOSATO, Marisa, GREY JR., Ronald Lee, BRODNEY, Michael Aaron, MEDEK, Ales, BLIGH, Cavan McKeon, OVERHOFF, Kirk Alan, HURLEY, Dennis James, CLARK, Michael Philip, MAXWELL, John Patrick, DAMAGNEZ, Veronique, XU, Jinwang, FIMOGNARI, Robert Francis, LAI, Mei-Hsiu, BANDARAGE, Upul Keerthi, HALL, Amy Beth, TAPLEY, Timothy Lewis, ROEPER, Stefanie, LIU, Siying, GIROUX, Simon, TANG, Qing
• Format: Patent
• Language: French
• Published: 23.03.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I):tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.