Composés pour le traitement de la toxicomanie
L'invention concerne de nouveaux composés ayant la structure de la formule (i) : qui sont utiles pour le traitement de mammifères pour la dépendance vis-à-vis de substances toxicomanogènes, par exemple de toxicomanie à un agent de production de dopamine tel que la cocaïne, la morphine, les amph...
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| Main Authors | , , , , , , |
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| Format | Patent |
| Language | French |
| Published |
01.09.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | L'invention concerne de nouveaux composés ayant la structure de la formule (i) : qui sont utiles pour le traitement de mammifères pour la dépendance vis-à-vis de substances toxicomanogènes, par exemple de toxicomanie à un agent de production de dopamine tel que la cocaïne, la morphine, les amphétamines, la nicotine et/ou l'alcool. L'invention concerne également des compositions pharmaceutiques comprenant une quantité thérapeutiquement efficace d'un composé de formule (i) et des procédés d'utilisation des composés de formule (i) dans le traitement de toxicomanie à un agent de production de dopamine.
Disclosed are N-[4-(2-oxo-1,2-dihydro-pyridin-4-yl)-benzyl]-benzamide derivatives which are useful as human mitochondrial aldehyde dehydrogenase (ALDH-2) inhibitors for treating chemical dependency on dopamine-producing agents such as cocaine, opiates, amphetamines, nicotine and alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of said compounds and methods of using the compounds in the treatment of addiction. |
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| AbstractList | L'invention concerne de nouveaux composés ayant la structure de la formule (i) : qui sont utiles pour le traitement de mammifères pour la dépendance vis-à-vis de substances toxicomanogènes, par exemple de toxicomanie à un agent de production de dopamine tel que la cocaïne, la morphine, les amphétamines, la nicotine et/ou l'alcool. L'invention concerne également des compositions pharmaceutiques comprenant une quantité thérapeutiquement efficace d'un composé de formule (i) et des procédés d'utilisation des composés de formule (i) dans le traitement de toxicomanie à un agent de production de dopamine.
Disclosed are N-[4-(2-oxo-1,2-dihydro-pyridin-4-yl)-benzyl]-benzamide derivatives which are useful as human mitochondrial aldehyde dehydrogenase (ALDH-2) inhibitors for treating chemical dependency on dopamine-producing agents such as cocaine, opiates, amphetamines, nicotine and alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of said compounds and methods of using the compounds in the treatment of addiction. |
| Author | LU, YAFAN VENKATARAMANI, CHANDRASEKAR STRICKLEY, ROBERT, G GRAUPE, MICHAEL CANNIZZARO, CARINA, E GUERRERO, JUAN, A ZABLOCKI, JEFF |
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| Title | Composés pour le traitement de la toxicomanie |
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