5-ALKYL-PYRIDO [2,3-D]PYRIMIDINES INHIBITRICES DE TYROSINE-KINASES

• Main Authors: TOOGOOD, PETER, LAURENCE, DOBRUSIN, ELLEN MYRA, BOOTH, RICHARD, JOHN
• Format: Patent
• Language: French
• Published: 20.12.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are compounds of the formula (I) wherein: R is hydrogen, alkyl, or cycloalkyl; R is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkynyl, lower alkenyl, nitrile, nitro, -COR , -CO2R , -CONR R , -CONR OR , -SO2NR R , -SO2NR R , -SO2R , -SO3R , formula (II), or -NR R ; Y is N or CR ; R is lower alkyl, haloalkyl, or aryl; X and Z are independently hydrogen, halogen, lower alkyl, lower alkoxy, trifluoromethyl, hydroxy, nitrile, nitro, -NR R , -N(O)R R , -NR R R W, -SR , -C(O)R , -CO2R , -CONR R , -SO2NR R , -SO2R , -SO3R , P(O)(OR )(OR ), -T(CH2)mQR , -C(O)T(CH2)mQR , or -NR C(O)T(CH2)mQR ; m is 1 to 6. These compounds are useful for treating cell proliferative disorders, such as cancer, atherosclerosis, and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases.