FORMULATION FOR BISPECIFIC T-CELL ENGAGERS (BITEs)
The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially suited for subcutaneous administration. The invention provides liquid compositions which minimize the formation of undesired polypeptide aggre...
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| Main Authors | , , , , |
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| Format | Patent |
| Language | English Lithuanian |
| Published |
25.07.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially suited for subcutaneous administration. The invention provides liquid compositions which minimize the formation of undesired polypeptide aggregates (dimers and/or multimers). The present invention further provides a method for minimizing the aggregation of polypeptides having antigen-binding domains in liquid compositions. |
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| AbstractList | The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially suited for subcutaneous administration. The invention provides liquid compositions which minimize the formation of undesired polypeptide aggregates (dimers and/or multimers). The present invention further provides a method for minimizing the aggregation of polypeptides having antigen-binding domains in liquid compositions. |
| Author | BUNTE, Thomas PETERS, Jörg TRILL, Thomas OLBRICH, Carsten WINTER, Jonas |
| Author_xml | – fullname: TRILL, Thomas – fullname: BUNTE, Thomas – fullname: WINTER, Jonas – fullname: PETERS, Jörg – fullname: OLBRICH, Carsten |
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| DocumentTitleAlternate | BISPECIFINIŲ T LĄSTELIŲ AKTYVATORIŲ (BITES) KOMPOZICIJA |
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| RelatedCompanies | Bayer Pharma Aktiengesellschaft |
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| Snippet | The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially... |
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| SubjectTerms | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | FORMULATION FOR BISPECIFIC T-CELL ENGAGERS (BITEs) |
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