PROCESS FOR PREPARING 7-SUBSTITUTED AMINO ACETAMIDO OXADETHIA CEPHALOSPORINS

Title compds. [I; R = II(R1,R2,R3 = H, lower alkyl, R1 and R2 combined lower alkylene), III(X = amino, O, S; R4,R5,R6 = H, lower alkyl, R4 and R5 combined lower alkylene, lower alkenylene, O-phenylene, azo group), IV(R8 = H, lower alkyl; R9 = aralkyl, aralkylene, aryl), substituted phenyl; Ar = aryl...

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Main Authors TSUJI DERUJI, NARISADA MASAJUKI, MATSUMURA HIROSHI, HAMAZIMA YOSHIO, YOSIOGA MITSURU, HAYASHI SADAO
Format Patent
LanguageEnglish
Korean
Published 25.08.1981
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Title compds. [I; R = II(R1,R2,R3 = H, lower alkyl, R1 and R2 combined lower alkylene), III(X = amino, O, S; R4,R5,R6 = H, lower alkyl, R4 and R5 combined lower alkylene, lower alkenylene, O-phenylene, azo group), IV(R8 = H, lower alkyl; R9 = aralkyl, aralkylene, aryl), substituted phenyl; Ar = aryl; Y = H, methoxy; Het is 5 or 6 membered aromatic heterocycle which comprise 1-4 hetero atom such as N, O or S; Z = hydroxy, carboxy protecting group; W = reactive functional group , having antibacterial activity, were prepd. by acylating α-amino group of compd. (V) with acylating agent(VI).
Bibliography:Application Number: KR19810002549