PROCESS FOR PREPARING PHENYL PIPERAZINES

Title compds. (I; R1 = benzyl, C1-6 alkyl-substituted phenyl; R2 = substituted phenyl; R3 = H, C1-4 alkyl; Q=furan, thiopen, oxazole, thiazole; m = 1-3; n = 0-1; when m,n and Q are 2, 0 and thiazol-5-yl, resp., R1 is not Me) were prepd. by redn. of II and III. Thus, 6.67 g (0.3 mol) 5-(4-chloropheny...

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Bibliographic Details
Main Authors JAMIESON W, VERGE J
Format Patent
LanguageEnglish
Korean
Published 17.08.1981
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Title compds. (I; R1 = benzyl, C1-6 alkyl-substituted phenyl; R2 = substituted phenyl; R3 = H, C1-4 alkyl; Q=furan, thiopen, oxazole, thiazole; m = 1-3; n = 0-1; when m,n and Q are 2, 0 and thiazol-5-yl, resp., R1 is not Me) were prepd. by redn. of II and III. Thus, 6.67 g (0.3 mol) 5-(4-chlorophenyl)-furanic acid was refluxed with 4.5 ml SOCl2 in 100 ml C6H5 followed by reaction with 4.5 ml (0.03 mol) (Et) 3N and 7.23 g (0.03 mol) N-(3-bromophenyl)-piperazine to give I(R1 = 4-chlorophenyl; Q = furan-2-yl; m = 1; n=0). IHCl was obtained by addn. of I with 5N HCl.
Bibliography:Application Number: KR19810001974