개선된 항원 결합 수용체

• Main Authors: CHEN GUOZHI, XU DAN, KLEIN CHRISTIAN, DAROWSKI DIANA, XU WEI, MOESSNER EKKEHARD, WEI HUAFENG, FREIMOSER GRUNDSCHOBER ANNE
• Format: Patent
• Language: Korean
• Published: 17.07.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본원 발명은 전반적으로, EU 넘버링에 따른 아미노산 돌연변이 P329G를 포함하는 Fc 도메인에 특이적으로 결합할 수 있는 인간화 항원 결합 수용체에 관한 것이다. 본원 발명은 또한, 치료 항체의 돌연변이된 Fc 도메인에 특이적으로 결합/상호작용함으로써 동원되는 항원 결합 수용체로 형질도입된 T 세포에 관한 것이다. The present invention generally relates to humanized antigen binding receptors capable of specific binding to an Fc domain comprising the amino acid mutation P329G according to EU numbering. The present invention also relates to T cells, transduced with an antigen binding receptor which is recruited by specifically binding to/interacting with the mutated Fc domain of therapeutic antibodies.