신규 다중-특이적 분자

본 개시내용은 SIRP-알파 및 1종 이상의 표적 항원에 특이적인 다중-특이적 분자, 그를 코딩하는 단리된 폴리뉴클레오티드, 그를 포함하는 제약 조성물, 및 그의 용도를 제공한다. 본 개시내용은 제공된 다중-특이적 분자가 SIRP-알파 결합 도메인, Fc 결합 도메인을 포함하는 활성화 수용체-결합 도메인, 및 표적 항원 결합 도메인을 포함하는 것인 다중-특이적 분자를 제공한다. The present disclosure provides multi-specific molecules specific for SIPR-alpha and on...

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Main Authors NIU XIAOFENG, WANG JING, QIU YANGSHENG, SUN DAWEI, WU ZHIHAO, JIANG HAIXIA, GAO RUI, LU HONGTAO, GENG YANAN
Format Patent
LanguageKorean
Published 26.03.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

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Abstract 본 개시내용은 SIRP-알파 및 1종 이상의 표적 항원에 특이적인 다중-특이적 분자, 그를 코딩하는 단리된 폴리뉴클레오티드, 그를 포함하는 제약 조성물, 및 그의 용도를 제공한다. 본 개시내용은 제공된 다중-특이적 분자가 SIRP-알파 결합 도메인, Fc 결합 도메인을 포함하는 활성화 수용체-결합 도메인, 및 표적 항원 결합 도메인을 포함하는 것인 다중-특이적 분자를 제공한다. The present disclosure provides multi-specific molecules specific for SIPR-alpha and one or more target antigens, isolated polynucleotide encoding the same, pharmaceutical compositions comprising the same, and the uses thereof. The present disclosure provides the multi-specific molecule provided comprises a SIRP-alpha binding domain, an activating receptor-binding domain comprising an Fe domain, and a target antigen binding domain.
AbstractList 본 개시내용은 SIRP-알파 및 1종 이상의 표적 항원에 특이적인 다중-특이적 분자, 그를 코딩하는 단리된 폴리뉴클레오티드, 그를 포함하는 제약 조성물, 및 그의 용도를 제공한다. 본 개시내용은 제공된 다중-특이적 분자가 SIRP-알파 결합 도메인, Fc 결합 도메인을 포함하는 활성화 수용체-결합 도메인, 및 표적 항원 결합 도메인을 포함하는 것인 다중-특이적 분자를 제공한다. The present disclosure provides multi-specific molecules specific for SIPR-alpha and one or more target antigens, isolated polynucleotide encoding the same, pharmaceutical compositions comprising the same, and the uses thereof. The present disclosure provides the multi-specific molecule provided comprises a SIRP-alpha binding domain, an activating receptor-binding domain comprising an Fe domain, and a target antigen binding domain.
Author LU HONGTAO
WANG JING
GAO RUI
NIU XIAOFENG
QIU YANGSHENG
WU ZHIHAO
SUN DAWEI
JIANG HAIXIA
GENG YANAN
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– fullname: GAO RUI
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Snippet 본 개시내용은 SIRP-알파 및 1종 이상의 표적 항원에 특이적인 다중-특이적 분자, 그를 코딩하는 단리된 폴리뉴클레오티드, 그를 포함하는 제약 조성물, 및 그의 용도를 제공한다. 본 개시내용은 제공된 다중-특이적 분자가 SIRP-알파 결합 도메인, Fc 결합 도메인을 포함하는 활성화...
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title 신규 다중-특이적 분자
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