유전자 전달에서 비바이러스 벡터로서의 수지상 구조

• Main Authors: RUPING KARL, TALUKDER POULAMI
• Format: Patent
• Language: Korean
• Published: 20.03.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC MACROMOLECULAR COMPOUNDS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; THEIR PREPARATION OR CHEMICAL WORKING-UP; VINEGAR; WINE

본원에는, 시험관내 및 생체내 둘 다에서 핵산의 세포내 전달을 용이하게 하기 위해, 핵산을 갖는 나노입자를 형성하도록 다른 지질 성분과의 조합으로 사용될 수 있는 신규한 수지상 구조가 개시된다. 또한, 질환 또는 병태를 치료 또는 예방하기 위한 그 화합물을 포함하는 나노입자 조성물 및 이의 이용 방법이 제공된다. Disclosed herein are novel dendritic structures that can be used in combination with other lipid components to form nanoparticles with nucleic acids. to facilitate the intracellular delivery of nucleic acids both in vitro and in vivo. Nanoparticle compositions comprising the compounds and methods for their use for treating or preventing diseases or conditions are also provided.