신규 핵산-가이드 뉴클레아제

본 개시내용은 신규 핵산-가이드 뉴클레아제, 및 게놈 편집을 위한 상기 뉴클레아제의 사용 방법을 제공한다. 나아가, 본 개시내용은 핵산-가이드 뉴클레아제, 상기 핵산-가이드 뉴클레아제와 복합체화하기 위한 이종성 가이드 핵산, 및 표적 영역에 결합하도록 구성된 편집 폴리뉴클레오타이드를 포함하는, 게놈 내 표적 영역을 편집하기 위한 시스템을 제공한다. The present disclosure provides novel nucleic acid-guided nucleases and methods of using the nucleases f...

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Main Authors SPINDLER MATTHEW JAMES, LIM YOONG WEARN, SIMONS JAN FREDRIK, SANDHU SAVREET KAUR, COLES GARRY, JOHNSON DAVID SCOTT, WAGNER ELLEN KATHLEEN, CARTER KYLE PIERCE, EDGAR ROBERT
Format Patent
LanguageKorean
Published 31.08.2023
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Abstract 본 개시내용은 신규 핵산-가이드 뉴클레아제, 및 게놈 편집을 위한 상기 뉴클레아제의 사용 방법을 제공한다. 나아가, 본 개시내용은 핵산-가이드 뉴클레아제, 상기 핵산-가이드 뉴클레아제와 복합체화하기 위한 이종성 가이드 핵산, 및 표적 영역에 결합하도록 구성된 편집 폴리뉴클레오타이드를 포함하는, 게놈 내 표적 영역을 편집하기 위한 시스템을 제공한다. The present disclosure provides novel nucleic acid-guided nucleases and methods of using the nucleases for genome editing. The present disclosure further provides a system for editing a target region in a genome comprising a nucleic acid-guided nuclease, a heterologous guide nucleic acid for complexing with the nucleic acid-guided nuclease, and an editing polynucleotide configured to bind to the target region.
AbstractList 본 개시내용은 신규 핵산-가이드 뉴클레아제, 및 게놈 편집을 위한 상기 뉴클레아제의 사용 방법을 제공한다. 나아가, 본 개시내용은 핵산-가이드 뉴클레아제, 상기 핵산-가이드 뉴클레아제와 복합체화하기 위한 이종성 가이드 핵산, 및 표적 영역에 결합하도록 구성된 편집 폴리뉴클레오타이드를 포함하는, 게놈 내 표적 영역을 편집하기 위한 시스템을 제공한다. The present disclosure provides novel nucleic acid-guided nucleases and methods of using the nucleases for genome editing. The present disclosure further provides a system for editing a target region in a genome comprising a nucleic acid-guided nuclease, a heterologous guide nucleic acid for complexing with the nucleic acid-guided nuclease, and an editing polynucleotide configured to bind to the target region.
Author WAGNER ELLEN KATHLEEN
COLES GARRY
JOHNSON DAVID SCOTT
LIM YOONG WEARN
EDGAR ROBERT
CARTER KYLE PIERCE
SIMONS JAN FREDRIK
SANDHU SAVREET KAUR
SPINDLER MATTHEW JAMES
Author_xml – fullname: SPINDLER MATTHEW JAMES
– fullname: LIM YOONG WEARN
– fullname: SIMONS JAN FREDRIK
– fullname: SANDHU SAVREET KAUR
– fullname: COLES GARRY
– fullname: JOHNSON DAVID SCOTT
– fullname: WAGNER ELLEN KATHLEEN
– fullname: CARTER KYLE PIERCE
– fullname: EDGAR ROBERT
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Snippet 본 개시내용은 신규 핵산-가이드 뉴클레아제, 및 게놈 편집을 위한 상기 뉴클레아제의 사용 방법을 제공한다. 나아가, 본 개시내용은 핵산-가이드 뉴클레아제, 상기 핵산-가이드 뉴클레아제와 복합체화하기 위한 이종성 가이드 핵산, 및 표적 영역에 결합하도록 구성된 편집 폴리뉴클레오타이드를...
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SubjectTerms BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
Title 신규 핵산-가이드 뉴클레아제
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