라파푸신 유도체 화합물 및 이의 사용 방법

본 개시내용은 천연 산물 FK506 및 라파마이신의 이뮤노필린 리간드 패밀리에 의해 영감을 받은 거대고리 화합물을 제공한다. FK506 및 라파마이신 결합 도메인을 함유한 거대고리의 라파푸신 라이브러리의 생성은 질환을 치료하기 위해 사용되는 약물을 개발하기 위한 새로운 단서로서 큰 가능성을 가질 것이다. The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and ra...

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Main Authors SCHMITT JENNIFER C, YAMAMOTO KANA, KUMAR PUNEET, LIU JUN, HONG SAM, ULLMAN BRETT R, SEMPLE JOSEPH E, SADAGOPAN MAGESH
Format Patent
LanguageKorean
Published 21.06.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract 본 개시내용은 천연 산물 FK506 및 라파마이신의 이뮤노필린 리간드 패밀리에 의해 영감을 받은 거대고리 화합물을 제공한다. FK506 및 라파마이신 결합 도메인을 함유한 거대고리의 라파푸신 라이브러리의 생성은 질환을 치료하기 위해 사용되는 약물을 개발하기 위한 새로운 단서로서 큰 가능성을 가질 것이다. The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.
AbstractList 본 개시내용은 천연 산물 FK506 및 라파마이신의 이뮤노필린 리간드 패밀리에 의해 영감을 받은 거대고리 화합물을 제공한다. FK506 및 라파마이신 결합 도메인을 함유한 거대고리의 라파푸신 라이브러리의 생성은 질환을 치료하기 위해 사용되는 약물을 개발하기 위한 새로운 단서로서 큰 가능성을 가질 것이다. The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.
Author LIU JUN
SADAGOPAN MAGESH
KUMAR PUNEET
YAMAMOTO KANA
SEMPLE JOSEPH E
SCHMITT JENNIFER C
HONG SAM
ULLMAN BRETT R
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Snippet 본 개시내용은 천연 산물 FK506 및 라파마이신의 이뮤노필린 리간드 패밀리에 의해 영감을 받은 거대고리 화합물을 제공한다. FK506 및 라파마이신 결합 도메인을 함유한 거대고리의 라파푸신 라이브러리의 생성은 질환을 치료하기 위해 사용되는 약물을 개발하기 위한 새로운 단서로서 큰...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title 라파푸신 유도체 화합물 및 이의 사용 방법
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