PAH를 치료하기 위한 항증식제

• Main Authors: JALAIE MEHRAN, CURTO JOHN M, LIAN YAJING, PALMER CYNTHIA LOUISE, YANG QINGYI, KANIA ROBERT STEVEN, BHATTACHARYA SAMIT KUMAR, NAIR SAJIV KRISHNAN, CHEN PING, BEHENNA DOUGLAS CARL, PETTERSSON MARTIN YOUNGJIN, SAMMONS MATTHEW FORREST, ZHANG LIYING, FREEMAN COOK KEVIN DANIEL, CAMERON KIMBERLY O, RUI EUGENE YUANJIN
• Format: Patent
• Language: Korean
• Published: 10.01.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 A, R1, R2, R3 및 R4가 본원에 정의된 바와 같은 것인 화학식 I의 화합물 및 그의 제약상 허용되는 염; 이러한 화합물 및 염을 포함하는 제약 조성물; 폐 고혈압 및 관련 질환, 예컨대 폐동맥 고혈압을 치료하기 위해 이러한 화합물, 염 및 조성물을 사용하는 방법; 비정상적 세포 성장, 예컨대 암을 치료하기 위해 이러한 화합물, 염 및 조성물을 사용하는 방법; 및 이러한 화합물, 염 및 조성물을 제조하는 방법에 관한 것이다. This invention relates to compounds of general Formula Iin which A, R1, R2, R3 and R4 are as defined herein, and the pharmaceutically acceptable salts thereof; to pharmaceutical compositions comprising such compounds and salts; to methods of using such compounds, salts and compositions for treating pulmonary hypertension and related diseases, like pulmonary arterial hypertension; to methods of using such compounds, salts and compositions for treating abnormal cell growth, such as cancer; and to processes to make such compounds, salts and compositions.