경구 전달 베타-락타마제 억제제의 고체 형태 및 이의 용도

• Main Authors: BURNS CHRISTOPHER J, TROUT ROBERT E. LEE, SIMPSON ROBERT, MESAROS EUGEN F, CONDON STEPHEN M, BOYD STEVEN A, ZULLI ALLISON L, DENG YIJUN, ROSEN LAWRENCE
• Format: Patent
• Language: Korean
• Published: 06.12.2021
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 명세서는 ((2-에틸부타노일)옥시)메틸 (R)-2-히드록시-3-프로피온아미도-3,4-디히드로-2H-벤조[e][1,2]옥사보리닌-8-카르복실레이트의 결정형을 개시한다. 또한 본 명세서는 ((2-에틸부타노일)옥시)메틸 (R)-2-히드록시-3-프로피온아미도-3,4-디히드로-2H-벤조[e][1,2]옥사보리닌-8-카르복실레이트의 결정형을 사용해 박테리아를 치료하는 방법을 개시한다. Disclosed herein are crystalline forms of ((2-Ethylbutanoyl)oxy)methyl (R)-2-hydroxy-3-propionamido-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylate. Also disclosed herein are methods of treating a bacterial with a crystalline form of ((2-Ethylbutanoyl)oxy)methyl (R)-2-hydroxy-3-propionamido-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylate.