CONJUGATION LINKERS CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LIKERS METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS

• Main Authors: YE ZHICHANG, XIE HONGSHENG, XU YIFANG, GUO HUIHUI, LI CHEN, YANG CHENGYU, YANG QINGLIANG, CAO MINJUN, ZHU HAIFENG, YANG YANLEI, HUANG YUANYUAN, ZHAO LINYAO, BAI LU, LI WENJUN, GAI SHUN, ZHOU XIAOMAI, JIA JUNXIANG, GUO ZHIXIANG, ZHAO YONGXIN ROBERT, YE HANGBO, WANG CHUNYAN, TONG QIANQIAN, GAO SHUIHONG
• Format: Patent
• Language: English; Korean
• Published: 20.10.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 프로피올일, 치환된 아크릴(아크릴로일) 또는 이 치환된 프로파노일의 그룹을 갖는 링커, 및 화합물, 특히 세포 독성제를 세포 결합 분자에 결합하기 위해 그러한 링커를 사용하는 것에 관한 것이다. The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds,...