IL-2 CD80 FORMULATIOM OF FUSION PROTEIN COMPRISING IL-2 PROTEIN AND CD80 PROTEIN
The present invention relates to a pharmaceutical formulation having improved stability of a fusion protein dimer containing modified IL-2 and CD80 proteins. The fusion protein dimer containing IL-2 and CD80 proteins can not only activate immune cells by IL-2, but also effectively regulate Treg cell...
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| Main Authors | , , , , , |
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| Format | Patent |
| Language | English Korean |
| Published |
28.09.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention relates to a pharmaceutical formulation having improved stability of a fusion protein dimer containing modified IL-2 and CD80 proteins. The fusion protein dimer containing IL-2 and CD80 proteins can not only activate immune cells by IL-2, but also effectively regulate Treg cells by CD80. The application of the formulation according to the present invention to the fusion protein dimer containing IL-2 and CD80 proteins not only can significantly improve the stability of the fusion protein dimer, but can also be used as a liquid formulation, leading to high commercial usability of the fusion protein dimer.
본 발명은 변형된 IL-2 단백질 및 CD80 단백질을 포함하는 융합단백질 이량체의 안정성을 향상시킨 약제학적 제형에 관한 것이다. IL-2 단백질 및 CD80 단백질을 포함하는 융합단백질 이량체는 IL-2에 의해 면역세포를 활성화시킬 수 있을 뿐 아니라, CD80에 의해 Treg 세포를 효과적으로 조절할 수 있다. 본 발명에 따른 제형을 IL-2 단백질 및 CD80 단백질을 포함하는 융합단백질 이량체에 적용할 경우 상기 융합단백질 이량체의 안정성이 현저히 증가할 뿐 아니라, 액상 제형으로 이용 가능하므로 융합단백질 이량체의 상업적 활용성을 높일 수 있다. |
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| AbstractList | The present invention relates to a pharmaceutical formulation having improved stability of a fusion protein dimer containing modified IL-2 and CD80 proteins. The fusion protein dimer containing IL-2 and CD80 proteins can not only activate immune cells by IL-2, but also effectively regulate Treg cells by CD80. The application of the formulation according to the present invention to the fusion protein dimer containing IL-2 and CD80 proteins not only can significantly improve the stability of the fusion protein dimer, but can also be used as a liquid formulation, leading to high commercial usability of the fusion protein dimer.
본 발명은 변형된 IL-2 단백질 및 CD80 단백질을 포함하는 융합단백질 이량체의 안정성을 향상시킨 약제학적 제형에 관한 것이다. IL-2 단백질 및 CD80 단백질을 포함하는 융합단백질 이량체는 IL-2에 의해 면역세포를 활성화시킬 수 있을 뿐 아니라, CD80에 의해 Treg 세포를 효과적으로 조절할 수 있다. 본 발명에 따른 제형을 IL-2 단백질 및 CD80 단백질을 포함하는 융합단백질 이량체에 적용할 경우 상기 융합단백질 이량체의 안정성이 현저히 증가할 뿐 아니라, 액상 제형으로 이용 가능하므로 융합단백질 이량체의 상업적 활용성을 높일 수 있다. |
| Author | KWON SOONTAK JANG MYOUNG HO LIM HEONCHANG CHO YOUNG GYU NAM SU YOUN OH YOUNG MIN |
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| Snippet | The present invention relates to a pharmaceutical formulation having improved stability of a fusion protein dimer containing modified IL-2 and CD80 proteins.... |
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| Title | IL-2 CD80 FORMULATIOM OF FUSION PROTEIN COMPRISING IL-2 PROTEIN AND CD80 PROTEIN |
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