융합 단백질 및 그 용도

• Main Authors: WANG XUEGONG, DING XIAORAN, TAN BIN, MIAO SHIWEI, LV MING
• Format: Patent
• Language: Korean
• Published: 27.07.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

종양 관련 항원에 특이적으로 결합하는 제1 결합 도메인 및 CD47 단백질에 특이적으로 결합하는 제2 결합 도메인을 포함하는 융합 단백질을 제공하고, 여기서 제2 결합 도메인은 인간 SIRPα 변이체 1의 돌연변이체를 포함한다. 융합 단백질과 관련된 면역접합체, 핵산 분자, 벡터, 조성물 및 세포 및 그 제조방법, 및 의약 제조에서의 이의 용도 또한 제공된다. Provided is a fusion protein, comprising a first binding domain that specifically binds a tumor-associated antigen, and a second binding domain that specifically binds a CD47 protein, wherein the second binding domain comprises a mutant of a human SIRPa variant 1. Also provided are an immunoconjugate, nucleic acid molecules, vectors, compositions and cells related to the fusion protein and preparation methods therefor, and the uses thereof in the preparation of medicaments.