PDK1 COMPOSITION FOR REVERSE CONTROL OF CELLULAR SENESCENCE COMPRISING PDK1 INHIBITOR

The present invention relates to a method for inducing reverse senescence by using a specific molecular target to restore aged cells to a young cell state. Particularly, the present invention relates to a composition for inducing reverse senescence including a PDK1 (Phosphoinositide-dependent kinase...

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Main Authors AN SU GYUN, CHO KWANG HYUN, CHO SI YOUNG, KIM HYUNG SU, LEE SOO BEOM, KANG JUN SOO
Format Patent
LanguageEnglish
Korean
Published 07.05.2020
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Abstract The present invention relates to a method for inducing reverse senescence by using a specific molecular target to restore aged cells to a young cell state. Particularly, the present invention relates to a composition for inducing reverse senescence including a PDK1 (Phosphoinositide-dependent kinase-1) inhibitor or a method for inducing reverse senescence including a step of treating aged cells with a PDK1 (Phosphoinositide-dependent kinase-1) inhibitor. According to the present invention, PDK1 is a protein that simultaneously controls MTOR and NF-κB among the main signal transferring proteins participating in cell senescence, and is a key protein determining cell growth-, division- and senescence-associated secretary phenotypes. It is determined that when PDK1 is inhibited temporarily, a part of aged cells is effectively restored to normal young cells and no phenotypes of aged cells are observed in such cells. Therefore, PDK1 suggests a new possibility to the current senescence treatment strategy focused on inducing apoptosis of aged cells, and can be used advantageously for development of anti- senescence materials and agents for treating senescence-associated diseases. 본 발명은 특정 분자 타겟을 이용하여 노화된 세포를 젊은 세포 상태로 되돌리는 역노화 유도 방법에 관한 것으로, 구체적으로는 PDK1(Phosphoinositide-dependent kinase-1) 저해제를 포함하는 역노화 유도용 조성물 또는 PDK1 저해제를 처리하는 단계를 포함하는 역노화 유도 방법에 관한 것이다. 본 발명에 따른 PDK1은 세포노화에 관여하는 주요 신호전달 단백질 중 MTOR과 NF-кB를 동시에 조절하는 단백질로서 세포의 성장, 분열 및 노화 관련 분비표현형을 결정하는 핵심 단백질이며, PDK1을 일시적으로 억제 시 노화된 세포 중 일부가 효과적으로 정상 젊은 세포로 가역화되며, 이러한 세포들에서는 더 이상 노화된 세포의 표현형이 관찰되지 않는 것을 확인하였다. 따라서, PDK1은 노화된 세포를 사멸 유도하는 전략에 치중되어 있는 현재의 노화치료전략에 새로운 가능성을 제시하고, 항노화 물질 및 노화 관련 질환 치료제 개발에 유용하게 사용될 수 있다.
AbstractList The present invention relates to a method for inducing reverse senescence by using a specific molecular target to restore aged cells to a young cell state. Particularly, the present invention relates to a composition for inducing reverse senescence including a PDK1 (Phosphoinositide-dependent kinase-1) inhibitor or a method for inducing reverse senescence including a step of treating aged cells with a PDK1 (Phosphoinositide-dependent kinase-1) inhibitor. According to the present invention, PDK1 is a protein that simultaneously controls MTOR and NF-κB among the main signal transferring proteins participating in cell senescence, and is a key protein determining cell growth-, division- and senescence-associated secretary phenotypes. It is determined that when PDK1 is inhibited temporarily, a part of aged cells is effectively restored to normal young cells and no phenotypes of aged cells are observed in such cells. Therefore, PDK1 suggests a new possibility to the current senescence treatment strategy focused on inducing apoptosis of aged cells, and can be used advantageously for development of anti- senescence materials and agents for treating senescence-associated diseases. 본 발명은 특정 분자 타겟을 이용하여 노화된 세포를 젊은 세포 상태로 되돌리는 역노화 유도 방법에 관한 것으로, 구체적으로는 PDK1(Phosphoinositide-dependent kinase-1) 저해제를 포함하는 역노화 유도용 조성물 또는 PDK1 저해제를 처리하는 단계를 포함하는 역노화 유도 방법에 관한 것이다. 본 발명에 따른 PDK1은 세포노화에 관여하는 주요 신호전달 단백질 중 MTOR과 NF-кB를 동시에 조절하는 단백질로서 세포의 성장, 분열 및 노화 관련 분비표현형을 결정하는 핵심 단백질이며, PDK1을 일시적으로 억제 시 노화된 세포 중 일부가 효과적으로 정상 젊은 세포로 가역화되며, 이러한 세포들에서는 더 이상 노화된 세포의 표현형이 관찰되지 않는 것을 확인하였다. 따라서, PDK1은 노화된 세포를 사멸 유도하는 전략에 치중되어 있는 현재의 노화치료전략에 새로운 가능성을 제시하고, 항노화 물질 및 노화 관련 질환 치료제 개발에 유용하게 사용될 수 있다.
Author CHO KWANG HYUN
CHO SI YOUNG
KANG JUN SOO
KIM HYUNG SU
LEE SOO BEOM
AN SU GYUN
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Snippet The present invention relates to a method for inducing reverse senescence by using a specific molecular target to restore aged cells to a young cell state....
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SubjectTerms FOODS OR FOODSTUFFS
FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT
THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
Title PDK1 COMPOSITION FOR REVERSE CONTROL OF CELLULAR SENESCENCE COMPRISING PDK1 INHIBITOR
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