T CARCHIMERIC ANTIGEN RECEPTORCAR WITH ANTIGEN BINDING DOMAINS TO THE T CELL RECEPTOR BETA CONSTANT REGION
본 발명은 TCR 베타 불변 영역 1(TRBC1) 또는 TRBC2에 선택적으로 결합하는 항원 결합 도메인을 포함하는 키메라 항원 수용체(CAR); 상기 CAR을 포함하는 상기 T 세포; 및 대상에서 T 세포 림프종 또는 백혈병의 치료를 위한 상기 세포의 용도에 관한 것이다. The present invention relates to a chimeric antigen receptor (CAR) which comprises an antigen-binding domain which selectively binds TCR beta cons...
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| Main Authors | , |
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| Format | Patent |
| Language | English Korean |
| Published |
12.03.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | 본 발명은 TCR 베타 불변 영역 1(TRBC1) 또는 TRBC2에 선택적으로 결합하는 항원 결합 도메인을 포함하는 키메라 항원 수용체(CAR); 상기 CAR을 포함하는 상기 T 세포; 및 대상에서 T 세포 림프종 또는 백혈병의 치료를 위한 상기 세포의 용도에 관한 것이다.
The present invention relates to a chimeric antigen receptor (CAR) which comprises an antigen-binding domain which selectively binds TCR beta constant region 1 (TRBC1) or TRBC2; cells; such a T cells comprising such a CAR; and the use of such cells for the treatment of a T-cell lymphoma or leukaemia in a subject. |
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| AbstractList | 본 발명은 TCR 베타 불변 영역 1(TRBC1) 또는 TRBC2에 선택적으로 결합하는 항원 결합 도메인을 포함하는 키메라 항원 수용체(CAR); 상기 CAR을 포함하는 상기 T 세포; 및 대상에서 T 세포 림프종 또는 백혈병의 치료를 위한 상기 세포의 용도에 관한 것이다.
The present invention relates to a chimeric antigen receptor (CAR) which comprises an antigen-binding domain which selectively binds TCR beta constant region 1 (TRBC1) or TRBC2; cells; such a T cells comprising such a CAR; and the use of such cells for the treatment of a T-cell lymphoma or leukaemia in a subject. |
| Author | MACIOCIA PAUL PULE MARTIN |
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| DocumentTitleAlternate | T 세포 수용체 베타 불변 영역에 대한 항원 결합 도메인을 갖는 키메라 항원 수용체(CAR) |
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| Snippet | 본 발명은 TCR 베타 불변 영역 1(TRBC1) 또는 TRBC2에 선택적으로 결합하는 항원 결합 도메인을 포함하는 키메라 항원 수용체(CAR); 상기 CAR을 포함하는 상기 T 세포; 및 대상에서 T 세포 림프종 또는 백혈병의 치료를 위한 상기 세포의 용도에 관한 것이다.
The... |
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| Title | T CARCHIMERIC ANTIGEN RECEPTORCAR WITH ANTIGEN BINDING DOMAINS TO THE T CELL RECEPTOR BETA CONSTANT REGION |
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