BRD4 및 JAK2 이중 억제제로서의 융합된 피리미딘 및 이의 사용 방법
본 발명은 융합된 피리미딘 화합물, 특히 피롤로피리미딘 화합물 및 이의 유도체, 이의 약학적 조성물, 그리고 BRD4 및 JAK2를 억제하는 방법 뿐만 아니라 이러한 화합물을 사용하여 암 및 백혈병과 같은 다양한 질환 및 상태를 치료하는 방법에 관한 것이다. 브로모도메인 결합 및 JAK 활성이 포함된다. The present invention relates to fused pyrimidine compounds, particularly pyrrolopyrimidine and thienopyrimidine compounds and de...
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| Main Authors | , , , |
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| Format | Patent |
| Language | Korean |
| Published |
06.12.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | 본 발명은 융합된 피리미딘 화합물, 특히 피롤로피리미딘 화합물 및 이의 유도체, 이의 약학적 조성물, 그리고 BRD4 및 JAK2를 억제하는 방법 뿐만 아니라 이러한 화합물을 사용하여 암 및 백혈병과 같은 다양한 질환 및 상태를 치료하는 방법에 관한 것이다. 브로모도메인 결합 및 JAK 활성이 포함된다.
The present invention relates to fused pyrimidine compounds, particularly pyrrolopyrimidine and thienopyrimidine compounds and derivatives thereof, pharmaceutical compositions thereof, and methods of inhibiting BRD4 and/or JAK2, as well as methods of treating various diseases and conditions, such as cancer and leukemia, with such compounds. Bromodomain binding and JAK activity are included. |
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| AbstractList | 본 발명은 융합된 피리미딘 화합물, 특히 피롤로피리미딘 화합물 및 이의 유도체, 이의 약학적 조성물, 그리고 BRD4 및 JAK2를 억제하는 방법 뿐만 아니라 이러한 화합물을 사용하여 암 및 백혈병과 같은 다양한 질환 및 상태를 치료하는 방법에 관한 것이다. 브로모도메인 결합 및 JAK 활성이 포함된다.
The present invention relates to fused pyrimidine compounds, particularly pyrrolopyrimidine and thienopyrimidine compounds and derivatives thereof, pharmaceutical compositions thereof, and methods of inhibiting BRD4 and/or JAK2, as well as methods of treating various diseases and conditions, such as cancer and leukemia, with such compounds. Bromodomain binding and JAK activity are included. |
| Author | KETHIRI RAGHAVA MADAN SACHIN RAJAIAH SANTOSH KUMAR KOTTURI UPADHAYAYA RAM SHANKAR |
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| Snippet | 본 발명은 융합된 피리미딘 화합물, 특히 피롤로피리미딘 화합물 및 이의 유도체, 이의 약학적 조성물, 그리고 BRD4 및 JAK2를 억제하는 방법 뿐만 아니라 이러한 화합물을 사용하여 암 및 백혈병과 같은 다양한 질환 및 상태를 치료하는 방법에 관한 것이다. 브로모도메인 결합 및... |
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| Title | BRD4 및 JAK2 이중 억제제로서의 융합된 피리미딘 및 이의 사용 방법 |
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