결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용

본 발명은 프로피올일, 치환된 아크릴(아크릴로일) 또는 이 치환된 프로파노일의 그룹을 갖는 링커, 및 화합물, 특히 세포 독성제를 세포 결합 분자에 결합하기 위해 그러한 링커를 사용하는 것에 관한 것이다. The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds,...

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Main Authors YE ZHICHANG, XIE HONGSHENG, XU YIFANG, GUO HUIHUI, LI CHEN, YANG CHENGYU, YANG QINGLIANG, CAO MINJUN, ZHU HAIFENG, YANG YANLEI, HUANG YUANYUAN, ZHAO LINYAO, BAI LU, LI WENJUN, GAI SHUN, ZHOU XIAOMAI, JIA JUNXIANG, GUO ZHIXIANG, ZHAO YONGXIN ROBERT, YE HANGBO, WANG CHUNYAN, TONG QIANQIAN, GAO SHUIHONG
Format Patent
LanguageKorean
Published 18.07.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract 본 발명은 프로피올일, 치환된 아크릴(아크릴로일) 또는 이 치환된 프로파노일의 그룹을 갖는 링커, 및 화합물, 특히 세포 독성제를 세포 결합 분자에 결합하기 위해 그러한 링커를 사용하는 것에 관한 것이다. The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
AbstractList 본 발명은 프로피올일, 치환된 아크릴(아크릴로일) 또는 이 치환된 프로파노일의 그룹을 갖는 링커, 및 화합물, 특히 세포 독성제를 세포 결합 분자에 결합하기 위해 그러한 링커를 사용하는 것에 관한 것이다. The present invention relates to linkers having a group of propiolyl, substituted acryl (acryloyl), or disubstituted propanoyl, and using such linkers for the conjugation of compounds, in particular, cytotoxic agents to a cell-binding molecule.
Author JIA JUNXIANG
YE ZHICHANG
WANG CHUNYAN
BAI LU
YE HANGBO
CAO MINJUN
GUO ZHIXIANG
ZHU HAIFENG
XU YIFANG
YANG CHENGYU
LI WENJUN
HUANG YUANYUAN
YANG QINGLIANG
ZHAO LINYAO
GAO SHUIHONG
GUO HUIHUI
ZHOU XIAOMAI
ZHAO YONGXIN ROBERT
GAI SHUN
TONG QIANQIAN
LI CHEN
YANG YANLEI
XIE HONGSHENG
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Snippet 본 발명은 프로피올일, 치환된 아크릴(아크릴로일) 또는 이 치환된 프로파노일의 그룹을 갖는 링커, 및 화합물, 특히 세포 독성제를 세포 결합 분자에 결합하기 위해 그러한 링커를 사용하는 것에 관한 것이다. The present invention relates to linkers...
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SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
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